Notes
Mrs. James' Medical Report

Warning This Section Does Contain Spoilers

Marybeth Anne James' Medical Report

The medical report for Mrs. James is a significant piece of this box. According to the medical record in the report there is an entry dated 9/26/1955 where she visits Dr. William Jenkins for a injury to her shoulder. Exactly nine months later she delivers a healthy baby boy named John William James. 

She then several years later has to be put on several different medications that will be displayed below:

Benzedrine: The world's first amphetamine

Searching for a decongestant and bronchodilator to replace ephedrine, the Benzedrine Inhaler came to be. It contained 325mg of an oily amphetamine base and almost nothing else. For congestion, it was meant to inhale every hour. It was then marketed in tablets and used to treat such things as narcolepsy, postencephalitic Parkinsonism, and minor depression. Mrs. James was using this to treat her, at this time, minor depression.


Iproniazid: first era of antidepressants

The first era of antidepressants started with Isoniazid, which was accidentally found to have positive effects on mood, appetite, and euphoric effects on patients with tuberculosis receiving the drug. The mood elevating properties of the drug were considered to be a side effect of the treatment, but became a primary effect in another class of drugs called antidepressants. In 1952 scientists discovered Iproniazid, another hydrazine derivative, an inhibited monoamine oxidase enzyme (MAO). It was used quite frequently until 1961, when it was withdrawn in most of the world due to high cases of hepatitis. It was commonly replaced by Phenelzine.


Phenelzine: commonly replaced Iproniazid

Phenelzine is classified as inhibited monoamine oxidase enzyme (MAO) and was commonly used to replace Iproniazid in 1961 when Iproniazid was discontinued in the United States and many other countries. It is used to treat many psychiatric illnesses like serious depression and severe depression coupled with anxiety.