Progestin/Estradiol Notes

Warning This Section Does Contain Spoilers



  • Hormonal contraception (either alone or with estrogen)
  • To prevent endometrial hyperplasia from unopposed estrogen in hormone replacement therapy
  • As antiandrogens (testosterone blockers)
  • Antigonadotropins (decrease the levels of androgen, estrogen, and progestogen sex steroid in the body
  • Cachexia to increase lean body mass by increasing appetite for people with cancer
  • Was approved as first oral contraceptive in United States in 1960 called Enovid



  • Mainly used in hormone replacement therapy during menopause
  • Can be used as a cancer treatment for men and women
  • Was first marketed in United States in 1943 for oral contraceptive use and called Estinyl